3D Scaffolds for regeneration of tissue

Naseem  Theilgaard

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3D Scaffolds for regeneration of tissue

Project period: 2006-2010

Serious illness such as cancer, extensive injuries resulting from traffic accidents or burns as well as arthritis and the conditions caused by arthritis often result in destruction of the natural tissue. The project addressed the critical need for the development of biomimetic 3D structures that actively support the regeneration of tissue, so that the lost and broken down tissue can be reestablished. Stemcells play an important role in the regeneration of tissues, and the primary purpose of the consortium in the short term was to generate new knowledge about how biomimetic structures can be functionalised to attract the residing stemcells from the surrounding and adjacent tissue. Reconstruction of the lost tissue with the help of biomimetic 3D structures will result in improved and safer patient treatment. The socio-economic benefits are clear; limitation of patient morbidity, improvement to quality of life of the patient and reduction of direct costs to society due to improved patient care and indirectly through limiting the number of days away from work.

The overall aim of this innovation consortium was to create a national focus point for the preparation of three-dimensional structures (3D scaffolds) for tissue engineering where chemical engineers, biologists, and microbiologists can contribute and exchange ideas and knowledge with scientists and clinicians in the university hospital world who have a deep understanding of the patient related problems and diseases.

The consortium creates a platform for state of the art in tissue engineering and hence support the companies through a series of innovative projects, involving new materials and products for tissue regeneration.

The consortium is based on a multidisciplinary cooperation, where engineers, biologists and molecular biologists within materials technology enter into cooperation with scientists and clinics with extensive knowledge in patient treatment and courses of illness.

Partners: Coloplast Research, Danfoss A/S, Danfoss Bionics, Interface Biotech, and Novozymes.

Knowledge institutions: The Danish Technological Institute, University of Southern Denmark, the former ‘University of Odense’ (now part of the University of Southern Denmark), and Bioneer (part of the Advanced Technology Group).