Project - New surface coatings ensure enhanced soft tissue integration of implants

Lars Pleth Nielsen

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Project - New surface coatings ensure enhanced soft tissue integration of implants

Project start 01.05.2014. Project completion 31.04.2018.

Development of surface coatings will improve the integration of implants in soft tissue, thereby lowering the risk of infections in connection with e.g. dental implants and electrodes for nerve stimulation.

Implants, penetrating mucous membranes and the skin, such as dental and other percutaneous implants, present an increased risk of infection. For example, a dental implant has a portion integrated into the jawbone, which ensures sufficient stability, and a portion penetrating the mucous membrane to support/carry the prosthetic reconstruction, which has very poor integration to the surrounding mucosa. This may complicate the cleaning of the implant, which in turn may increase the risk of infection resulting in bone destruction and possibly implant loss. Another critical area regards implants for nerve stimulation, for example for treatment of urinary incontinence, where a quick and effective anchoring of the electrode in the surrounding soft tissue is necessary for a successful result.

The ASTI project (Accelerated Soft Tissue Integration) aims at developing new surface technologies, facilitating an enhanced soft tissue integration of implants made of different materials. This is made possible through a number of technology tracks, e.g. micro and nanostructured coatings, antibiofilm properties of osteopontin extracted from milk, etc. Through these initiatives, materials with optimal properties for integration of soft tissue will be developed.

The consortium has all the necessary core competencies including leading manufacturers of implants and electrodes, knowledge of and equipment for purification of proteins, experts in polymer materials, microbial tests and diagnostics, in vivo testing, application-oriented coating development on an industrial scale and a strong network of national and international experts in particular in microbiology, chemistry, dentistry, and material science.

The project is divided into a screening phase and a demonstration phase. The screening phase identifies the most promising candidates from the technology tracks. These are subsequently tested in vivo and the final surfaces and materials are selected for the demonstration phase, where they are implemented and tested in products.

The screening phase is divided into the following work packages:

  • Nanostructured coatings based on Physical Vapour Deposition
  • Injection-moulded polymers, protein anchoring and surface texturing
  • Topographically structured polymers
  • Antibiofilm solutions

The aim is to bring the technologies developed during the project period at such a stage so that they will be ready for clinical tests.

The project will prioritize special tests and validation in in vivo models, IPR protection and dissemination, and application of the developed technologies will be prioritized in the project. In this way, the industrial relevance of the technologies is ensured.


  • Danish Technological Institute
  • Elos Medtech Pinol A/S
  • Neurodan A/S
  • Arla Foods Ingredients Group P/S
  • Inmold Biosystems A/S
  • iNANO Aarhus University, Faculty of Dentistry
  • Malmö Högskola

Link in Danish

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