Structural characterization of biomolecules with SAXS
Reduce risk in drug development with structural insight in solution
Nearly 90 percent of drug candidates fail in clinical development, often due to insufficient understanding of structural behavior in solution. Aggregation, unfolding, and unwanted interactions can compromise formulation stability, shelf-life, and efficacy.
Our SAXS-based characterization services reveal your biomolecule's structure, stability, and interactions under realistic conditions — using as little as 20 µL of sample per measurement.
How can Danish Technological Institute help you?
At the Danish Technological Institute, we deliver end-to-end Small-Angle X-ray Scattering (SAXS) services at world-class synchrotron facilities, analyzing your samples in their native solution state at relevant concentrations.
Below are some examples of challenges that we can help you address:
- Drug design and lead screening
Confirm size, oligomeric state, folding, and stability early — and eliminate problematic candidates before further investment. SAXS provides a direct structural basis supporting lead ranking for proteins, mAbs, ADCs, and nucleic acids (DNA/RNA). - Higher Order Structure (HOS) characterization
Document tertiary and quaternary structure in solution to meet regulatory expectations for biologics. SAXS provides direct empirical evidence of correct folding and structural integrity for submissions and biosimilarity assessments. - Formulation development and optimization
Screen buffers, pH, excipients, and concentrations to identify stable formulations. We support a high-throughput workflow compatible with 96-well plates enabling data-driven formulation decisions. - Stability assessment
Detect aggregation, unfolding, and phase transitions under controlled conditions. Characterize the effects of temperature, ionic strength, and pH on structural integrity to predict shelf-life and product quality issues. - Batch-to-batch quality control
Verify reproducibility across production batches using structural fingerprints in solution — a rapid, sensitive QC method from early development to commercial manufacturing.
Benefits of choosing our SAXS services
Advantage | Details |
| Low sample consumption | From 20 µL per measurement - ideal for early-stage development |
| High-throughput screening | 96-well plate format for automated formulation screening |
| Native solution conditions | Realistic concentrations, pH, temperatures, and buffers |
| Expert analysis and reporting | PhD-level scientists deliver comprehensive, actionable reports |
| Accelerated timelines | Rapid synchrotron access shortens sample-to-decision time |
Contact Us
Talk to our specialist Mathias Huss-Hansen, PhD, about how SAXS structural characterization can support your drug development process - from lead screening, formulation, and development to regulatory documentation or QC needs.