Synchrotron imaging of low density materials

Susan Rudd Cooper

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Kollage af 3D visualiseringer fra røntgen og HiP tomografi

Synchrotron imaging of low density materials

Synchrotron tomography allows for non-destructive imaging of low-density materials

Low density materials, including biological samples and materials composed primarily of organic compounds, can be hard to image in 3D because they have a low X-ray absorption. X-ray absorption increases with an element’s atomic number, and therefore materials made of carbon (atomic number 6) absorb only a small amount of the irradiation, thus giving very poor contrast in imaging.

With the addition of phase contrast tomography, this is all about to change. Using phase contrast, even biological samples can be studied with high resolution and contrast - without staining or similar invasive sample preparation.

Low density materials can be hard to image because they have a low X-ray contrast. With phase contrast, we see a game-changer for our customers in the food- and medico industries.
Susan Cooper, Senior Specialist, synchrotron mediator, DTI

    Sammenligning af tværsnit fra virtuelle pellets fra mikro-ct og HiP-CTCASE STUDY - PELLETS & PHASE CONTRAST

    In this case study, pellets were visualized by both laboratory Micro-CT and phase contrast tomography (HiP-CT, synchrotron source). With the addition of phase contrast, it's possible to distinguish between different types of organic material, and the increased signal-to-noise ratio also greatly increases the impact in visualization and possibilities to quantify data.

    C3D visualisering af fisk, tværsnitASE STUDY - SOFT TISSUE IN SMALL FISH

    In this case study, we used phase contrast tomography at the ESRF to image fish with unprecedented detail in the internal organs. The purpose of the investigation was to study the digestion of various experimental diets. With the three-dimensional tomography data, it's possible to study the digestion of experimental feed as it passes through the fish.

    HiP-CT (Hierarchical Phase-Contrast Tomography)

    One of the common ways to image biological materials has been to use a contrast agent, where a light material is treated with heavy elements that absorb into the material to increase the contrast.  Another way to image materials made of light elements is by measuring samples using phase contrast, where changes in material density determine the image contrast instead of elemental identity. In addition, synchrotron sources can be used instead of lab X-ray sources so we get more signal.

    This type of analysis can be used on anything made of light elements, including:

    • Biological samples
    • Food
    • Composites
    • Pharmaceuticals

     

    Danish Technological Institute's role as a mediator

    At DTI, we can help you obtain access to exciting techniques like HiP-CT. We can help you with the whole process from experimental design, to data collection, and data analysis. Have you ever thought about using big science to push your research forward? What do you want to see in detail?

    Get in touch with us!

    • Susan Cooper, Senior Specialist (srco@dti.dk / +45 7220 1754)
    • Erik Wisaeus, Business Manager (erwi@dti.dk / +45 7220 2681)
    • ... or use the contact form.